Natural controlled HIV infection: Preserved HIV-specific immunity despite undetectable replication competent virus
نویسندگان
چکیده
منابع مشابه
Immunity to Human Immunodeficiency Virus (HIV) Infection
The advent of highly active antiretroviral therapy (HAART) in 1996 revolutionized life expectancy and quality of life of people infected by HIV in the developed Countries. Nowadays, HIV-infected patients can positively think that their life expectancy is comparable to that of people of the same age and with the same pattern of risk factors Indeed, there are clear demonstrations that mortality p...
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Progressive immune dysfunction and AIDS develop in most cases of human immunodeficiency virus type 1 (HIV-1) infection but in only 25 to 30% of persons with HIV-2 infection. However, the natural history and immunologic responses of individuals with dual HIV-1 and HIV-2 infection are largely undefined. Based on our previous findings, we hypothesized that among patients with dual infection the co...
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UNLABELLED We present the development and characterization of a replication-competent controlled herpes simplex virus 1 (HSV-1). Replication-essential ICP4 and ICP8 genes of HSV-1 wild-type strain 17syn+ were brought under the control of a dually responsive gene switch. The gene switch comprises (i) a transactivator that is activated by a narrow class of antiprogestins, including mifepristone a...
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Env-pseudotyped viruses are valuable reagents for studies of HIV-1 neutralizing antibodies. It is often assumed that all pseudovirus particles are capable of only a single round of infection, making them a safe alternative to work with live HIV-1. In this study, we show that some Env-pseudotyped virus preparations give rise to low levels of replication-competent virus. These levels did not comp...
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A critical knowledge gap in the field of HIV cure research is how best to measure the persistence of replication-competent HIV in the form of intact but latent proviruses. One approach to curing HIV is to eradicate all replication-competent HIV from an individual. It is unlikely that any method, now or in the future, will be able to declare with certainty that all intact proviruses have been el...
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ژورنال
عنوان ژورنال: Virology
سال: 2005
ISSN: 0042-6822
DOI: 10.1016/j.virol.2005.06.001